Academic Writing

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single-use diaphragm valve allows a paradigm shift to single-use technology: from manual systems to systems which can be automated for fault-free operation and with complying documentation. The trend towards simplified plant designs upstream and downstream and the effective prevention of cross-contamination risks is constantly giving an ever more important profile to single-use disposable technology - especially in pharmaceutical process engineering. In the manufacture of small batch sizes up to approx. 2,000 l, which are required in research, and pilot production systems; single-use technology is increasingly being used. The secondary processes for cleaning and sterilisation (CIP/SIP) that are well-known and required for classic stainless steel material plant designs are in practice no longer necessary at all with single-use plants and processes. The necessary sterility is guaranteed through the sterilization by gamma rays of all the process components which were used. This reduces not only the investment costs of such a plant, but also eliminates the extremely time-consuming cleaning validation for operating media that are no longer required. The single-use diaphragm valve with pneumatic actuator has been developed for the increasingly required demand for the automation capability of single-use processes. Valve body and actuator are connected to each other by a patented technology: after the application process, the valve body is disconnected from the actuator, and mult