Amazon ec2 Server and MySQL configuration

Amazon ec2 Server Configuration. I have an ec2 server with amazon. This is windows and has sql express installed. I have a CRM package with a MySql database installed on the server. The client machines can not connect to the database. I need the server to be configured to allow the client machines to connect to the database and create a mapped drive on the server. I will require detailed instruction on how to configure the client machines once the server is configured correctly. I am looking for an experienced amazon server administrator to look after this server in the future also.